Karthick Sivalingam Anbazhagan
Thrombosis, Fluid mechanics and Medical Devices
I was born in Erode and grew up in the coastal city of Chennai (India) where I earned my Bachelors in Chemical Engineering at IIT-Madras. I completed my M.S.E in Nanotechnology from University of Pennsylvania, under the guidance of Prof. Dennis Discher. My thesis project involved studies on cancer cell differentiation using slow release of retinoid drug delivery from filomicelle nanoparticles and bioderived hydrogels. I developed a deep interest in solving biomedical engineering problems and currently pursue my doctoral research in Bioengineering at Georgia Tech, where I hope to distinguish myself.
Transcatheter Aortic Valve Replacement or TAVR is a minimally invasive catheter-based approach to treat severe aortic stenosis, which has assumed significance due to the drive to extend the procedure to intermediate and low risk patient community. An understanding of the fluid mechanics of TAVR and the implications for thrombosis is critical to the long-term success of these blood contacting devices. Using bench scale fluidic circuits of the aortic valve section employing human blood, I seek to understand how geometrical features of the valve, device deployment and patient anatomy can be risk factors for blood clotting via flow based mechanisms. We employ CT images of TAVR patients to obtain patient specific geometric data.